Product DescriptionRecombinant HEK293 cell line expressing human PDE10A2 (phosphodiesterase 10A ,accession number NM_006661).FormatEach vial contains 1 X 10^6 cells in 1 ml of 10% DMSO.IntroductionPDE10A plays a key role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. PDE10A hydrolyzes both cAMP and cGMP to nucleoside 5"-monophosphate, but exhibits higher affinity for cAMP, and it utilizes cAMP more efficiently as a substrate (Fujishige K. et al., 1999). cAMP is an critical second messenger that is required for the proper biological responses of cells to hormones and other extracellular signals. It is required for cellular communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones (Alewijnse A.E. et al., 1997). cAMP is also involved in the activation of protein kinases and ion channel regulation.

ReferencesFujishige K, et al. (1999). "Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)." J. Biol. Chem. 274 (26): 18438–45. Alewijnse, AE, et al. (1997). “Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active Gs-coupled receptors.” FEBS Letters 419 (2-3): 171-174.