IDE-1 is an inducer of definitive endoderm (IDE) from embryonic stem (ES) cells. It functions in part via activation of TGF-β signaling, as evident by Smad2 phosphorylation. IDE-1 Induces definitive endoderm formation in mouse and human embryonic stem cells (EC50 = 125 nM).
CAS Number
1160927-48-9
Chemical Formula
C15H18N2O5
Chemical Name
(Z)-2-((2-(6-carboxyhexanoyl)hydrazono)methyl)benzoic acid
Molecular Weight
306.31
QC Specifications
MASS Spec
Mouse ESC culture for toxicity
Shipping Information
on blue ice
Storage
4°C protected from light
Stability
Stable for up to 6 months from date of receipt when stored as directed.
Reference
1.Borowiak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348.
