PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 has no effect on a panel of 27 other kinases. PD 0325901 could enhance reprogramming efficiency when using it with ALKs inhibitor SB431542 (1).
CAS Number
391210-10-9
Chemical Formula
C16H14F3IN2O4
Chemical Name
N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
Molecular Weight
482.19
QC Specifications
MASS Spec
Mouse ESC culture for toxicity
Shipping Information
on blue ice
Storage
-20°C protected from light
Stability
Stable for up to 6 months from date of receipt when stored as directed.
Reference
1. Lin, T., et al. A chemical platform for improved induction of human iPSCs. (2009) Nat Methods 6: 805-808
