Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK). It protects human embryonic stem cells (hESCs) from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction (1).
CAS Number
1226056-71-8
Chemical Formula
C15H13N5OS
Chemical Name
N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
Molecular Weight
311.36
QC Specifications
MASS Spec
Mouse ESC culture for toxicity
Shipping Information
on blue ice
Storage
-20°C protected from light
Stability
Stable for up to 6 months from date of receipt when stored as directed.
Reference
1. Xu, Y., et al. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. (2010) Proc Natl Acad Sci USA 107: 8129-8134
